Insights - CLP 2026: New Hazard Classes and What They Mean for Your IUCLID Dossiers

The revised CLP Regulation (Classification, Labelling and Packaging) brings the biggest change to EU chemical hazard classification in years. New hazard classes are entering application, and they directly affect how you classify substances and build your IUCLID dossiers. If you register or supply chemicals in the EU, here is what you need to know — and do — in 2026.

What is changing

Delegated Regulation (EU) 2023/707 added new hazard classes to CLP that go beyond the classic physical, health, and environmental categories. The new classes are:

• ED HH — Endocrine disruptors for human health
• ED ENV — Endocrine disruptors for the environment
• PBT — Persistent, Bioaccumulative and Toxic
• vPvB — very Persistent, very Bioaccumulative
• PMT — Persistent, Mobile and Toxic
• vPvM — very Persistent, very Mobile

These properties were previously assessed under REACH, but they are now formal CLP hazard classes with their own classification criteria, labelling consequences, and notification obligations.

Key deadlines

The new classes apply on a staggered timeline. The headline dates:

In short: 2026 is the year these classes become unavoidable for most portfolios. Existing registrations are not grandfathered — they must be reviewed and updated.

What it means for your IUCLID dossiers

1. Re-screen your portfolio. Any substance with persistence, bioaccumulation, mobility, or endocrine-activity data is a candidate for one of the new classes. Identify them before the deadline, not after a compliance check.
2. Update classification records in IUCLID. The GHS / classification and labelling sections need to reflect the new hazard classes where they apply. Make sure your IUCLID version supports the updated picklists and format.
3. Refresh the C&L Inventory notification. New classifications must flow through to your ECHA Classification & Labelling notifications.
4. Check your SDS and labels downstream. A new hazard class can change Safety Data Sheets and supply-chain communication, not just the dossier.

Don’t get caught out by an outdated IUCLID version

A practical trap: the new hazard classes rely on recent IUCLID releases and format updates. If you run an older self-hosted IUCLID build, you may not have the correct classification fields at all — and upgrading on your own schedule means downtime and IT effort right when deadlines are tightest.

This is exactly where managed hosting helps. On 4chems.com, your IUCLID, CHESAR, and QSAR Toolbox environment is always on the latest ECHA release — typically within a few days of publication — so the correct CLP classification fields are there when you need them, with no manual upgrades on your side.

Next step: Want a fast review of how CLP 2026 affects your registered substances? Talk to an expert and we will help you scope the work before the May deadlines.